"Intracellular re-routing of prion protein prevents propagation of PrP(Sc) and delays "Long-term memory consolidation: The role of RNA-binding proteins with

av D Pullirsch · 2010 · Citerat av 72 — proteins are characterized by a c-terminal deaminase domain (yellow box) and a variable number of double stranded RNA-binding domains.

Incubation of A431 lysate with labeled AR UTR RNA enriches HuR RBP; incubation with only poly(A) 25 RNA or HuR is a member of the embryonic lethal abnormal vision (ELAV) family of RNA-binding proteins . It can shuttle between the nucleus and the cytoplasm, and the stabilization of ARE-mRNA by HuR is believed to be linked to its localization in the cytoplasm (12,13). The ubiquitously expressed mRNA‐binding protein (mRBP) HuR (ELAVL1) is a postulated stress‐relevant protein that binds to adenylate uridylate (AU)‐rich sites within regulatory mRNA targets and regulates their expression via post‐transcriptional mechanisms . These binding sites typically reside within 3‘‐UTRs of target transcripts. 2012-06-01 · The mammalian RNA-binding protein (RBP) HuR associates with numerous mRNAs encoding proteins with roles in cell division, cell survival, immune response, and differentiation.

Hur rna binding protein

Here the authors show that HuR represses adipogenesis in white and brown adipose tissue by stabilizing Insig1 and ELAV-like protein 1 or HuR is a protein that in humans is encoded by the ELAVL1 gene. The protein encoded by this gene is a member of the ELAVL protein family. This encoded protein contains 3 RNA-binding domains and binds cis-acting AU-rich elements. One of its best-known functions is to stabilize mRNAs in order to regulate gene expression. 2018-04-20 · METHODS AND RESULTS: Herein, we show that, as evidenced by ribonucleoprotein immunoprecipitation assay, RNA binding protein Hu antigen R/ELAV like RNA binding protein 1 (HuR/ELAVL1) and myocyte enhancer factor-2C (MEF2C) transcription factor mRNA are associated.

This protein functions through post-transcriptional modification of mRNA transcripts by changing the nucleotide content of the RNA. One of the best-characterized RNA-binding proteins in animals is HuR (encoded for by Elavl1), a ubiquitously-expressed member of the embryonic lethal abnormal vision (ELAV)/Hu family of RNA-binding proteins. In the nucleus, HuR is involved in various functions, including RNA splicing and nuclear export.

May 1, 2011 The RNA-Binding Protein HuR Promotes Glioma Growth and Treatment Resistance. Natalia Filippova, Xiuhua Yang, Yimin Wang, G. Yancey

In many cancerous settings, HuR is not only overexpressed, but it is “overactive” as denoted by increased subcellular localization within the cytoplasm. 2019-12-03 · Herein, we show that the ablation of RNA-binding protein HuR in NSCs impairs adult but not embryonic neurogenesis. HuR is predominantly expressed in the cytoplasm of embryonic NSCs but translocates into the nucleus of adult NSCs. ubiquitously expressed mRNA-binding protein (mRBP) HuR(ELAVL1)isapostulatedstress-relevantproteinthat binds to adenylate uridylate (AU)–rich sites within regu-latory mRNA targets and regulates their expression via post-transcriptional mechanisms (12).

Jun 18, 2020 The RNA-binding protein (RBP) Hu antigen R (HuR), also known as embryonic lethal abnormal vision-like protein 1 (ELAVL1), is a ubiquitously

This protein functions through post-transcriptional modification of mRNA transcripts by changing the nucleotide content of the RNA. One of the best-characterized RNA-binding proteins in animals is HuR (encoded for by Elavl1), a ubiquitously-expressed member of the embryonic lethal abnormal vision (ELAV)/Hu family of RNA-binding proteins. In the nucleus, HuR is involved in various functions, including RNA splicing and nuclear export.

What Is New? The cardiac sodium channel α‐subunit mRNA is upregulated by the transcription factor myocyte enhancer factor‐2C (MEF2C). MEF2C is upregulated by binding of RNA stabilizing protein, HuR (alias ELAVL1).
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compellingly demonstrate in mice that increased HuR activity in myeloid cells has a protective role in the onset of pathologic intestinal inflammation (i.e., colitis) and colitis-associated cancer (CAC). HuR is an RNA-binding protein that resides predominantly in the nucleus but shuttles to the cytosol carrying mRNAs containing a uridylate-rich region in the 3'untranslated region. RNA-binding protein HuR binds to and stabilizes OIP5-AS1. Among the vast collection of lncRNAs annotated for human sequences (9837 lncRNAs, Ensembl v72) (35, 36), OIP5-AS1 was identified as the human homolog of cyrano, a lncRNA that plays a role in zebrafish development , and showed significant conservation in gene structure .

RNA pol 1. The RNA-binding protein, HuR, associates with the HuR mRNA, but the consequences of this interaction are unknown. Here, we use human The RNA Club Stockholm serves a platform for scientific exchange for people will give a seminar on RNA-binding proteins tomorrow Tuesday at SciLifeLab av vilka sjukdomar, men hur många av oss vill egentligen ha den informationen? Accession Number, NP_001185765.1.
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Poly(C) Binding Proteins (CP1 and CP2). These RNA-binding proteins regulate mRNA stability (HuR) and mRNA turnover and translation (CP1 and CP2). The negative control RNA [poly(A) 25 RNA] does not contain HuR or poly(C) BP binding sites. Incubation of A431 lysate with labeled AR UTR RNA enriches HuR RBP; incubation with only poly(A) 25 RNA or

Human antigen R (HuR) is an RNA-binding protein that regulates the stability, translation, and nucleus-to-cytoplasm shuttling of its target mRNAs. While HuR is normally localized within the nucleus, it has been shown that HuR binds mRNAs in the nucleus and then escorts the mRNAs to the cytoplasm where HuR protects them from degradation. RNA‐binding protein HuR suppresses senescence through Atg7 mediated autophagy activation in diabetic intervertebral disc degeneration 1 INTRODUCTION. Low back pain is a common symptom of various medical conditions, and up to 80% of the population may 2 MATERIAL AND METHODS.

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Human antigen R (HuR) is an RNA binding protein that binds to the AU-rich element (ARE) of specific mRNA and is involved in the export and stabilization of ARE-mRNA. Our recent report unveiled that the E4orf6 gene deleted oncolytic adenovirus (dl355) replicated for certain types of cancers where ARE-mRNA is stabilized.

Here, we investigate the potential contribution of the RNA binding protein (RBP) human antigen R (HuR) on the posttranscriptional regulation of ABCA1 expression HuR/ELAVL1 is an RNA-binding protein involved in differentiation and stress response that acts primarily by stabilizing messenger RNA (mRNA) targets.

Assistant Professor, Uppsala University - ‪‪Citerat av 1 479‬‬ - ‪Microbiology‬ - ‪RNA-binding protein‬ - ‪RNA biology‬ - ‪sRNA‬ - ‪Bacterial pathogenesis‬

Human antigen R (HuR) is a member of the Hu family of RNA-binding proteins. This molecule, which was first described in tumors nearly two decades ago, has recently received much attention in tumor-related research because it regulates the expression of many tumor-associated molecules through posttranscriptional regulatory mechanisms, thereby affecting biological characteristics.

RNA‐binding protein HuR suppresses senescence through Atg7 mediated autophagy activation in diabetic intervertebral disc degeneration 1 INTRODUCTION. Low back pain is a common symptom of various medical conditions, and up to 80% of the population may 2 MATERIAL AND METHODS. All treatments on The RNA binding protein HuR determines the differential translation of autism-associated FoxP subfamily members in the developing neocortex The RNA-binding protein HuR is a negative regulator in adipogenesis Abstract. Human antigen R (HuR) is an essential regulator of RNA metabolism, but its function in metabolism remains Introduction. Obesity is characterized by excessive lipid storage in adipose tissue, leading to an increase of The RNA-binding protein HuR binds to elements rich in adenylate and uridylate (AU-rich elements) in target mRNAs and stabilizes them against degradation. The complete spectrum of genes whose expression is regulated by HuR and are the basis for the broad range of cellular functions of the protein is incompletely understood. HuR, a member of the ELAV family of RNA-binding proteins, is a multifunctional protein that has been implicated in the regulation of various aspects of RNA metabolism (Hinman and Lou, 2008).